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The Asp99-Arg188 Salt Bridge of the Pseudomonas aeruginosa HemO is Critical in Allowing Conformational Flexibility During Catalysis.
The P. aeruginosa iron-regulated heme oxygenase (HemO) is required within the host for the utilization of heme as an iron source. As iron is essential for survival and virulence HemO represents a novel antimicrobial target. We recently characterized small molecule inhibitors that bind to an alloster...
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| Publicado no: | J Biol Inorg Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6203605/ https://ncbi.nlm.nih.gov/pubmed/30194537 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-018-1609-x |
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