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Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of P. aeruginosa

Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in releasing iron is the oxidative cleavage of heme by HemO. A recent computer aided drug design (CADD) study identified several inhibitors of the...

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Autori principali: Hom, Kellie, Heinzl, Geoffrey A., Eakanunkul, Suntara, Lopes, Pedro E. M., Xue, Fengtian, MacKerell, Alexander D., Wilks, Angela
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643010/
https://ncbi.nlm.nih.gov/pubmed/23379514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301819k
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