Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa

New therapeutic targets are required to combat multidrug resistant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to links between iron and virulence and dependence on heme as an iron source during infection. Herein we report the synthesis and activity of...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Heinzl, Geoffrey A., Huang, Weiliang, Yu, Wenbo, Giardina, Bennett J., Zhou, Yue, MacKerell, Alexander D., Wilks, Angela, Xue, Fengtian
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080841/
https://ncbi.nlm.nih.gov/pubmed/27353344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00757
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