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Iminoguanidines as Allosteric Inhibitors of the Iron-Regulated Heme Oxygenase (HemO) of Pseudomonas aeruginosa

New therapeutic targets are required to combat multidrug resistant infections, such as the iron-regulated heme oxygenase (HemO) of Pseudomonas aeruginosa, due to links between iron and virulence and dependence on heme as an iron source during infection. Herein we report the synthesis and activity of...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Heinzl, Geoffrey A., Huang, Weiliang, Yu, Wenbo, Giardina, Bennett J., Zhou, Yue, MacKerell, Alexander D., Wilks, Angela, Xue, Fengtian
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5080841/
https://ncbi.nlm.nih.gov/pubmed/27353344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00757
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