MR-based spatial normalization improves [(18)F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease

The positron emission tomography (PET) tracer [(18)F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington’s disease (HD). In this study we investigated [(18)F]MNI-659 uptake in the Q175 mouse model of HD. Given the focal striatal dist...

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Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Bertoglio, Daniele, Verhaeghe, Jeroen, Kosten, Lauren, Thomae, David, Van der Linden, Annemie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203386/
https://ncbi.nlm.nih.gov/pubmed/30365550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206613
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