Noninvasive Relative Quantification of [(11)C]ABP688 PET Imaging in Mice Versus an Input Function Measured Over an Arteriovenous Shunt

Impairment of the metabotropic glutamate receptor 5 (mGluR5) has been implicated with various neurologic disorders. Although mGluR5 density can be quantified with the PET radiotracer [(11)C]ABP688, the methods for reproducible quantification of [(11)C]ABP688 PET imaging in mice have not been thoroug...

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Pubblicato in:Front Neurol
Autori principali: Verhaeghe, Jeroen, Bertoglio, Daniele, Kosten, Lauren, Thomae, David, Verhoye, Marleen, Van Der Linden, Annemie, Wyffels, Leonie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Neurology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036254/
https://ncbi.nlm.nih.gov/pubmed/30013509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2018.00516
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