MR-based spatial normalization improves [(18)F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease

The positron emission tomography (PET) tracer [(18)F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington’s disease (HD). In this study we investigated [(18)F]MNI-659 uptake in the Q175 mouse model of HD. Given the focal striatal dist...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Bertoglio, Daniele, Verhaeghe, Jeroen, Kosten, Lauren, Thomae, David, Van der Linden, Annemie, Stroobants, Sigrid, Wityak, John, Dominguez, Celia, Mrzljak, Ladislav, Staelens, Steven
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2018
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6203386/
https://ncbi.nlm.nih.gov/pubmed/30365550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206613
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