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MR-based spatial normalization improves [(18)F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease
The positron emission tomography (PET) tracer [(18)F]MNI-659, selective for phosphodiesterase 10A (PDE10A), is a promising tool to assess an early biomarker for Huntington’s disease (HD). In this study we investigated [(18)F]MNI-659 uptake in the Q175 mouse model of HD. Given the focal striatal dist...
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| Publicado no: | PLoS One |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6203386/ https://ncbi.nlm.nih.gov/pubmed/30365550 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0206613 |
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