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Predicting the Onset of Nonlinear Pharmacokinetics
When analyzing the pharmacokinetics (PK) of drugs, one is often faced with concentration C vs. time curves, which display a sharp transition at a critical concentration C (crit). For C > C (crit), the curve displays linear clearance and for C < C (crit) clearance increases in a nonlinear manne...
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| Publicado no: | CPT Pharmacometrics Syst Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202475/ https://ncbi.nlm.nih.gov/pubmed/30196577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12316 |
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