A Flexible Nonlinear Feedback System That Captures Diverse Patterns of Adaptation and Rebound

An important approach to modeling tolerance and adaptation employs feedback mechanisms in which the response to the drug generates a counter-regulating action which affects the response. In this paper we analyze a family of nonlinear feedback models which has recently proved effective in modeling to...

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Main Authors: Gabrielsson, Johan, Peletier, Lambertus A.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2008
Teme:
Review Article/Themed Issue: Bioinformatics and Computational Advances in the Pharmaceutical Sciences/Guest Editor: Murali Raman
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751452/
https://ncbi.nlm.nih.gov/pubmed/18446507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9007-x
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