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A Flexible Nonlinear Feedback System That Captures Diverse Patterns of Adaptation and Rebound
An important approach to modeling tolerance and adaptation employs feedback mechanisms in which the response to the drug generates a counter-regulating action which affects the response. In this paper we analyze a family of nonlinear feedback models which has recently proved effective in modeling to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751452/ https://ncbi.nlm.nih.gov/pubmed/18446507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9007-x |
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