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A Flexible Nonlinear Feedback System That Captures Diverse Patterns of Adaptation and Rebound

An important approach to modeling tolerance and adaptation employs feedback mechanisms in which the response to the drug generates a counter-regulating action which affects the response. In this paper we analyze a family of nonlinear feedback models which has recently proved effective in modeling to...

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Bibliografske podrobnosti
Main Authors: Gabrielsson, Johan, Peletier, Lambertus A.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751452/
https://ncbi.nlm.nih.gov/pubmed/18446507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9007-x
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