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Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification
In this paper we present a mathematical analysis of the basic model for target mediated drug disposition (TMDD). Assuming high affinity of ligand to target, we give a qualitative characterisation of ligand versus time graphs for different dosing regimes and derive accurate analytic approximations of...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Springer US
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3446204/ https://ncbi.nlm.nih.gov/pubmed/22851162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-012-9260-6 |
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