Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures

Double-strand breaks (DSBs) are extremely detrimental DNA lesions that can lead to cancer-driving mutations and translocations. Non-homologous end joining (NHEJ) and homologous recombination (HR) represent the two main repair pathways operating in the context of chromatin to ensure genome stability....

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Publié dans:Mol Cell
Auteurs principaux: Clouaire, Thomas, Rocher, Vincent, Lashgari, Anahita, Arnould, Coline, Aguirrebengoa, Marion, Biernacka, Anna, Skrzypczak, Magdalena, Aymard, François, Fongang, Bernard, Dojer, Norbert, Iacovoni, Jason S., Rowicka, Maga, Ginalski, Krzysztof, Côté, Jacques, Legube, Gaëlle
Format: Artigo
Langue:Inglês
Publié: Cell Press 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202423/
https://ncbi.nlm.nih.gov/pubmed/30270107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.020
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