Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer

Although defects in the RB1 tumour suppressor are one of the more common driver alterations found in triple-negative breast cancer (TNBC), therapeutic approaches that exploit this have not been identified. By integrating molecular profiling data with data from multiple genetic perturbation screens,...

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Vydáno v:Oncogene
Hlavní autoři: Brough, Rachel, Gulati, Aditi, Haider, Syed, Kumar, Rahul, Campbell, James, Knudsen, Erik, Pettitt, Stephen J., Ryan, Colm J., Lord, Christopher J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202330/
https://ncbi.nlm.nih.gov/pubmed/29915391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0368-z
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