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Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer
Approximately 30% of triple-negative breast cancers (TNBCs) exhibit functional loss of the RB tumor suppressor, suggesting a target for precision intervention. Here, we use drug screens to identify agents specifically antagonized by the retinoblastoma tumor suppressor (RB) using CDK4/6 inhibitors. A...
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| Veröffentlicht in: | Cell Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5967622/ https://ncbi.nlm.nih.gov/pubmed/29386107 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.01.022 |
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