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Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer
Although defects in the RB1 tumour suppressor are one of the more common driver alterations found in triple-negative breast cancer (TNBC), therapeutic approaches that exploit this have not been identified. By integrating molecular profiling data with data from multiple genetic perturbation screens,...
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| Publié dans: | Oncogene |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6202330/ https://ncbi.nlm.nih.gov/pubmed/29915391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0368-z |
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