Cocaine self-administration alters transcriptome-wide responses in the brain’s reward circuitry

BACKGROUND: Global changes in gene expression underlying circuit and behavioral dysregulation associated with cocaine addiction remain incompletely understood. Here, we show how a history of cocaine self-administration (SA) “re-programs” transcriptome-wide responses throughout the brain’s reward cir...

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Publicado en:Biol Psychiatry
Main Authors: Walker, Deena M., Cates, Hannah M., Loh, Yong-Hwee E., Purushothaman, Immanuel, Ramakrishnan, Aarthi, Cahill, Kelly M., Lardner, Casey K., Godino, Arthur, Kronman, Hope G., Rabkin, Jacqui, Lorsch, Zachary S., Mews, Philipp, Doyle, Marie A., Feng, Jian, Labonté, Benoit, Koo, Ja Wook, Bagot, Rosemary C., Logan, Ryan W., Seney, Marianne L., Calipari, Erin S., Shen, Li, Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202276/
https://ncbi.nlm.nih.gov/pubmed/29861096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2018.04.009
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