Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2

Early life stress increases risk for depression. Here we establish a “two-hit” stress model in mice wherein stress at a specific postnatal period increases susceptibility to adult social defeat stress and causes long-lasting transcriptional alterations that prime the ventral tegmental area (VTA)—a b...

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Publicado no:Science
Main Authors: Peña, Catherine J., Kronman, Hope G., Walker, Deena M., Cates, Hannah M., Bagot, Rosemary C., Purushothaman, Immanuel, Issler, Orna, Loh, Yong-Hwee Eddie, Leong, Tin, Kiraly, Drew D., Goodman, Emma, Neve, Rachael L., Shen, Li, Nestler, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539403/
https://ncbi.nlm.nih.gov/pubmed/28619944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan4491
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