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The role of tubulin-tubulin lattice contacts in the mechanism of microtubule dynamic instability

Microtubules form from longitudinally and laterally assembling tubulin α/β-dimers. The assembly induces strain in tubulin, resulting in cycles of microtubule catastrophe and regrowth. This so-called dynamic instability is governed by GTP hydrolysis that renders the microtubule lattice unstable, but...

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Bibliografische gegevens
Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Manka, Szymon W., Moores, Carolyn A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201834/
https://ncbi.nlm.nih.gov/pubmed/29967541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0087-8
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