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Pseudo‐repeats in doublecortin make distinct mechanistic contributions to microtubule regulation
Doublecortin (DCX) is a neuronal microtubule‐associated protein (MAP) indispensable for brain development. Its flexibly linked doublecortin (DC) domains—NDC and CDC—mediate microtubule (MT) nucleation and stabilization, but it is unclear how. Using high‐resolution time‐resolved cryo‐EM, we mapped ND...
Gespeichert in:
| Veröffentlicht in: | EMBO Rep |
|---|---|
| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7726794/ https://ncbi.nlm.nih.gov/pubmed/33051979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.202051534 |
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