Impact of the Myosin Modulator Mavacamten on Force Generation and Cross‐Bridge Behavior in a Murine Model of Hypercontractility

BACKGROUND: Recent studies suggest that mavacamten (Myk461), a small myosin‐binding molecule, decreases hypercontractility in myocardium expressing hypertrophic cardiomyopathy‐causing missense mutations in myosin heavy chain. However, the predominant feature of most mutations in cardiac myosin bindi...

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Vydáno v:J Am Heart Assoc
Hlavní autoři: Mamidi, Ranganath, Li, Jiayang, Doh, Chang Yoon, Verma, Sujeet, Stelzer, Julian E.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201428/
https://ncbi.nlm.nih.gov/pubmed/30371160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009627
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