Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma with SP-2509 engages the endoplasmic reticulum stress response

Multi-agent chemotherapeutic regimes remain the cornerstone treatment for Ewing sarcoma, the second most common bone malignancy diagnosed in pediatric and young adolescent populations. We have reached a therapeutic ceiling with conventional cytotoxic agents, highlighting the need to adopt novel appr...

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Publicado no:Mol Cancer Ther
Main Authors: Pishas, Kathleen I., Drenberg, Christina D., Taslim, Cenny, Theisen, Emily R., Johnson, Kirsten M., Saund, Ranajeet S., Pop, Ioana L, Crompton, Brian D., Lawlor, Elizabeth R, Tirode, Franck, Mora, Jaume, Delattre, Olivier, Beckerle, Mary C., Callen, David F., Sharma, Sunil, Lessnick., Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201274/
https://ncbi.nlm.nih.gov/pubmed/29997151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-18-0373
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