Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a binding interaction at the colchicine site on β-tubulin. A water-soluble phosphate prodr...

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Veröffentlicht in:Medchemcomm
Hauptverfasser: Maguire, Casey J., Chen, Zhi, Mocharla, Vani P., Sriram, Madhavi, Strecker, Tracy E., Hamel, Ernest, Zhou, Heling, Lopez, Ramona, Wang, Yifan, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Royal Society of Chemistry 2018
Schlagworte:
Chemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201230/
https://ncbi.nlm.nih.gov/pubmed/30429970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00322j
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