Synthesis of dihydronaphthalene analogues inspired by combretastatin A-4 and their biological evaluation as anticancer agents

The natural products colchicine and combretastatin A-4 (CA4) have provided inspiration for the discovery and development of a wide array of derivatives and analogues that inhibit tubulin polymerization through a binding interaction at the colchicine site on β-tubulin. A water-soluble phosphate prodr...

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Udgivet i:Medchemcomm
Main Authors: Maguire, Casey J., Chen, Zhi, Mocharla, Vani P., Sriram, Madhavi, Strecker, Tracy E., Hamel, Ernest, Zhou, Heling, Lopez, Ramona, Wang, Yifan, Mason, Ralph P., Chaplin, David J., Trawick, Mary Lynn, Pinney, Kevin G.
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2018
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201230/
https://ncbi.nlm.nih.gov/pubmed/30429970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8md00322j
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