Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low preval...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Robert, Marie Gladys, Foguim Tsombeng, Francis, Gendrot, Mathieu, Mosnier, Joel, Amalvict, Rémy, Benoit, Nicolas, Torrentino-Madamet, Marylin, Pradines, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Epidemiology and Surveillance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201094/
https://ncbi.nlm.nih.gov/pubmed/30181370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00374-18
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