Absence of a High Level of Duplication of the Plasmepsin II Gene in Africa

Resistance to piperaquine has been associated with the amplification of the plasmepsin II gene in Cambodia. None of the 175 African isolates that we analyzed had plasmepsin II gene amplification (piperaquine 50% inhibitory concentration ranged from 0.94 to 137.5 nM), suggesting there is a low preval...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Robert, Marie Gladys, Foguim Tsombeng, Francis, Gendrot, Mathieu, Mosnier, Joel, Amalvict, Rémy, Benoit, Nicolas, Torrentino-Madamet, Marylin, Pradines, Bruno
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Epidemiology and Surveillance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201094/
https://ncbi.nlm.nih.gov/pubmed/30181370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00374-18
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