Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction...

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Publicado en:Antimicrob Agents Chemother
Autores principales: Miller, William R., Singh, Kavindra V., Arias, Cesar A., Murray, Barbara E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Experimental Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201062/
https://ncbi.nlm.nih.gov/pubmed/30150459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01158-18
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