Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Miller, William R., Singh, Kavindra V., Arias, Cesar A., Murray, Barbara E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201062/
https://ncbi.nlm.nih.gov/pubmed/30150459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01158-18
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