Cefazolin plus Clavulanic Acid Overcomes the Inoculum Effect in a Methicillin-Susceptible Staphylococcus aureus (MSSA) Rat Endocarditis Model

BACKGROUND: The inoculum effect (InE) refers to an increase in the MIC of an antibiotic when a large burden of bacteria is present. MSSA producing type A or C β-lactamase (β-lac) that display this effect may be at risk of clinical failure when treated with cefazolin (CFZ) for a deep-seated infection...

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Published in:Open Forum Infect Dis
Main Authors: Miller, William, Singh, Kavindra, Arias, Cesar, Murray, Barbara
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632191/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofx162.031
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