Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis

We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Miller, William R., Singh, Kavindra V., Arias, Cesar A., Murray, Barbara E.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2018
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201062/
https://ncbi.nlm.nih.gov/pubmed/30150459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01158-18
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