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The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence
The tumor suppressor F-box protein 31 (FBXO31) is indispensable for maintaining genomic stability. Its levels drastically increase following DNA damage, leading to cyclin D1 and MDM2 degradation and G(1) and G(2)/M arrest. Prolonged arrest in these phases leads to cellular senescence. Accordingly, F...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6200945/ https://ncbi.nlm.nih.gov/pubmed/30171069 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005354 |
| Oznake: |
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