The SCF(FBXO46) ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence

The tumor suppressor F-box protein 31 (FBXO31) is indispensable for maintaining genomic stability. Its levels drastically increase following DNA damage, leading to cyclin D1 and MDM2 degradation and G(1) and G(2)/M arrest. Prolonged arrest in these phases leads to cellular senescence. Accordingly, F...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Choppara, Srinadh, Ganga, Sankaran, Manne, Rajeshkumar, Dutta, Parul, Singh, Shailza, Santra, Manas Kumar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200945/
https://ncbi.nlm.nih.gov/pubmed/30171069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005354
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