Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation

The F-box protein FBXO31 is a tumor suppressor that is encoded in 16q24.3, for which there is loss of heterozygosity in various solid tumors. FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Choppara, Srinadh, Malonia, Sunil K., Sankaran, Ganga, Green, Michael R., Santra, Manas Kumar
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5798317/
https://ncbi.nlm.nih.gov/pubmed/29343641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705954115
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