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Degradation of FBXO31 by APC/C is regulated by AKT- and ATM-mediated phosphorylation
The F-box protein FBXO31 is a tumor suppressor that is encoded in 16q24.3, for which there is loss of heterozygosity in various solid tumors. FBXO31 serves as the substrate-recognition component of the SKP/Cullin/F-box protein class of E3 ubiquitin ligases and has been shown to direct degradation of...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5798317/ https://ncbi.nlm.nih.gov/pubmed/29343641 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705954115 |
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