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F-box protein FBXO31 directs degradation of MDM2 to facilitate p53-mediated growth arrest following genotoxic stress

The tumor suppressor p53 plays a critical role in maintaining genomic stability. In response to genotoxic stress, p53 levels increase and induce cell-cycle arrest, senescence, or apoptosis, thereby preventing replication of damaged DNA. In unstressed cells, p53 is maintained at a low level. The majo...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Malonia, Sunil K., Dutta, Parul, Santra, Manas Kumar, Green, Michael R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4507212/
https://ncbi.nlm.nih.gov/pubmed/26124108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510929112
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