Yap/Taz mediates mTORC2-stimulated fibroblast activation and kidney fibrosis

Our previously published study demonstrated that mammalian target of rapamycin complex 2 (mTORC2) signaling mediates TGFβ1-induced fibroblast activation. However, the underlying mechanisms for mTORC2 in stimulating fibroblast activation remain poorly understood. Here, we found that TGFβ1 could stimu...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Gui, Yuan, Li, Jianzhong, Lu, Qingmiao, Feng, Ye, Wang, Mingjie, He, Weichun, Yang, Junwei, Dai, Chunsun
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2018
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200934/
https://ncbi.nlm.nih.gov/pubmed/30154246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004073
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