The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

M2 macrophage polarization is known to underlie kidney fibrosis. We previously reported that most of the members of the Wnt family of signaling proteins are induced in fibrotic kidneys. Dysregulation of the signaling protein Wnt5a is associated with fibrosis, but little is known about the role of Wn...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Feng, Ye, Liang, Yan, Zhu, Xingwen, Wang, Mingjie, Gui, Yuan, Lu, Qingmiao, Gu, Mengru, Xue, Xian, Sun, Xiaoli, He, Weichun, Yang, Junwei, Johnson, Randy L., Dai, Chunsun
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2018
Konular:
Signal Transduction
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302175/
https://ncbi.nlm.nih.gov/pubmed/30333225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005457
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