The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

M2 macrophage polarization is known to underlie kidney fibrosis. We previously reported that most of the members of the Wnt family of signaling proteins are induced in fibrotic kidneys. Dysregulation of the signaling protein Wnt5a is associated with fibrosis, but little is known about the role of Wn...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Feng, Ye, Liang, Yan, Zhu, Xingwen, Wang, Mingjie, Gui, Yuan, Lu, Qingmiao, Gu, Mengru, Xue, Xian, Sun, Xiaoli, He, Weichun, Yang, Junwei, Johnson, Randy L., Dai, Chunsun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6302175/
https://ncbi.nlm.nih.gov/pubmed/30333225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005457
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