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RNF144A sustains EGFR signaling to promote EGF-dependent cell proliferation
RNF144A is a single-pass transmembrane RBR E3 ligase that interacts with and degrades cytoplasmic DNA-PKcs, which is an epidermal growth factor receptor (EGFR)-interacting partner. Interestingly, RNF144A expression is positively correlated with EGFR mRNA and protein levels in several types of cancer...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6200932/ https://ncbi.nlm.nih.gov/pubmed/30171075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002887 |
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