Breeding Characteristics and Dose-dependent Blood Pressure Responses of Transgenic Cyp1a1–Ren2 Rats

Hypertension is a leading risk factor for cardiovascular and chronic kidney disease. A new rodent model (transgenic male Cyp1a1–Ren2 rats) provides reversible induction of hypertension through the addition of indole-3-carbinol (I3C) to the diet, without the need for surgical intervention, thus givin...

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Опубликовано в: :Comp Med
Главные авторы: Leader, Catherine J, Clark, Barbara J, Hannah, Amber R, Sammut, Ivan A, Wilkins, Gerard T, Walker, Robert J
Формат: Artigo
Язык:Inglês
Опубликовано: American Association for Laboratory Animal Science 2018
Предметы:
Rat Model
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200032/
https://ncbi.nlm.nih.gov/pubmed/30185285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.30802/AALAS-CM-17-18000026
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