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Direct Renin Inhibition with Aliskiren Normalizes Blood Pressure in Cyp1a1-Ren2 Transgenic Rats with Inducible ANG II-Dependent Malignant Hypertension

BACKGROUND: Cyp1a1-Ren2 transgenic rats [strain name: TGR(Cyp1a1Ren2)], administered indole-3-carbinol (I3C) develop angiotensin (ANG) II-dependent hypertension due to hepatic expression of the Ren2 renin gene. Although AT(1) receptor blockade prevents the development of hypertension and normalizes...

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Bibliografske podrobnosti
Main Authors: Howard, Catherine G., Mullins, John J., Mitchell, Kenneth D.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082604/
https://ncbi.nlm.nih.gov/pubmed/21358304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MAJ.0b013e31820fa8da
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