Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

The limited number of hematopoietic stem cells (HSCs) in umbilical cord blood (UCB) units restricts their use for stem cell transplantation. Ex vivo treatment of UCB-CD34(+) cells with valproic acid (VPA) increases the number of transplantable HSCs. In this study, we demonstrate that HSC expansion i...

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Bibliografske podrobnosti
izdano v:Blood Adv
Main Authors: Papa, Luena, Zimran, Eran, Djedaini, Mansour, Ge, Yongchao, Ozbek, Umut, Sebra, Robert, Sealfon, Stuart C., Hoffman, Ronald
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Hematopoiesis and Stem Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199653/
https://ncbi.nlm.nih.gov/pubmed/30348672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024273
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