Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

The limited number of hematopoietic stem cells (HSCs) in umbilical cord blood (UCB) units restricts their use for stem cell transplantation. Ex vivo treatment of UCB-CD34(+) cells with valproic acid (VPA) increases the number of transplantable HSCs. In this study, we demonstrate that HSC expansion i...

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Bibliografiset tiedot
Julkaisussa:Blood Adv
Päätekijät: Papa, Luena, Zimran, Eran, Djedaini, Mansour, Ge, Yongchao, Ozbek, Umut, Sebra, Robert, Sealfon, Stuart C., Hoffman, Ronald
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society of Hematology 2018
Aiheet:
Hematopoiesis and Stem Cells
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199653/
https://ncbi.nlm.nih.gov/pubmed/30348672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024273
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