Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

The limited number of hematopoietic stem cells (HSCs) in umbilical cord blood (UCB) units restricts their use for stem cell transplantation. Ex vivo treatment of UCB-CD34(+) cells with valproic acid (VPA) increases the number of transplantable HSCs. In this study, we demonstrate that HSC expansion i...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Blood Adv
Hoofdauteurs: Papa, Luena, Zimran, Eran, Djedaini, Mansour, Ge, Yongchao, Ozbek, Umut, Sebra, Robert, Sealfon, Stuart C., Hoffman, Ronald
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2018
Onderwerpen:
Hematopoiesis and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199653/
https://ncbi.nlm.nih.gov/pubmed/30348672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024273
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items