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Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation
The limited number of hematopoietic stem cells (HSCs) in umbilical cord blood (UCB) units restricts their use for stem cell transplantation. Ex vivo treatment of UCB-CD34(+) cells with valproic acid (VPA) increases the number of transplantable HSCs. In this study, we demonstrate that HSC expansion i...
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| 出版年: | Blood Adv |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Hematology
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6199653/ https://ncbi.nlm.nih.gov/pubmed/30348672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024273 |
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