Ex vivo human HSC expansion requires coordination of cellular reprogramming with mitochondrial remodeling and p53 activation

The limited number of hematopoietic stem cells (HSCs) in umbilical cord blood (UCB) units restricts their use for stem cell transplantation. Ex vivo treatment of UCB-CD34(+) cells with valproic acid (VPA) increases the number of transplantable HSCs. In this study, we demonstrate that HSC expansion i...

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Papa, Luena, Zimran, Eran, Djedaini, Mansour, Ge, Yongchao, Ozbek, Umut, Sebra, Robert, Sealfon, Stuart C., Hoffman, Ronald
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Hematopoiesis and Stem Cells
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199653/
https://ncbi.nlm.nih.gov/pubmed/30348672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2018024273
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