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Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

Metabolism in the liver often determines the overall clearance rates of many pharmaceuticals. Furthermore, induction or inhibition of the liver drug metabolism enzymes by perpetrator drugs can influence the metabolism of victim drugs (drug-drug interactions). Therefore, determining liver-drug intera...

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書目詳細資料
發表在:Drug Metab Dispos
Main Authors: Underhill, Gregory H., Khetani, Salman R.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199629/
https://ncbi.nlm.nih.gov/pubmed/30135245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.083295
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