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Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

Metabolism in the liver often determines the overall clearance rates of many pharmaceuticals. Furthermore, induction or inhibition of the liver drug metabolism enzymes by perpetrator drugs can influence the metabolism of victim drugs (drug-drug interactions). Therefore, determining liver-drug intera...

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Bibliografske podrobnosti
izdano v:Drug Metab Dispos
Main Authors: Underhill, Gregory H., Khetani, Salman R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199629/
https://ncbi.nlm.nih.gov/pubmed/30135245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.083295
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