P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity

Preclinical evaluation of drug candidates in experimental animal models is an essential step in drug development. Humanized mouse models have emerged as a promising alternative to traditional animal models. The purpose of this mini-review is to provide a brief survey of currently available mouse mod...

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Detalhes bibliográficos
Publicado no:Drug Metab Dispos
Main Authors: Bissig, Karl-Dimiter, Han, Weiguo, Barzi, Mercedes, Kovalchuk, Nataliia, Ding, Liang, Fan, Xiaoyu, Pankowicz, Francis P., Zhang, Qing-Yu, Ding, Xinxin
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Special Section – New Models in Drug Metabolism and Transport
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199624/
https://ncbi.nlm.nih.gov/pubmed/30093418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.118.083303
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