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Copy Number Alterations in Tumor Genomes Deleting Antineoplastic Drug Targets Partially Compensated by Complementary Amplifications

Background/Aim: Genomic DNA copy number alterations (CNAs) are frequent in tumors and have been catalogued by The Cancer Genome Atlas project. Emergence of chemoresistance frequently renders drug therapies ineffective. Materials and Methods: We analyzed how CNAs recurrently found in the genomes of T...

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Publicat a:Cancer Genomics Proteomics
Autors principals: TRAN, HA VU, KIEMER, ALEXANDRA K, HELMS, VOLKHARD
Format: Artigo
Idioma:Inglês
Publicat: International Institute of Anticancer Research 2018
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199575/
https://ncbi.nlm.nih.gov/pubmed/30194077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.21873/cgp.20095
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