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Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity
TDP-43 is the major disease protein associated with amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD-TDP). Here we identify the transcriptional elongation factor Ell—a shared component of little elongation complex (LEC) and super elongatio...
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| Izdano u: | Nat Commun |
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| Glavni autori: | , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6199344/ https://ncbi.nlm.nih.gov/pubmed/30353006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06543-0 |
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