Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

Abnormalities of brain connectivity and signal transduction are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function and lower myelination in SZ....

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Pubblicato in:Transl Psychiatry
Autori principali: McPhie, Donna L., Nehme, Ralda, Ravichandran, Caitlin, Babb, Suzann M., Ghosh, Sulagna Dia, Staskus, Alexandra, Kalinowski, Amy, Kaur, Rupinderjit, Douvaras, Panagiotis, Du, Fei, Ongur, Dost, Fossati, Valentina, Eggan, Kevin, Cohen, Bruce M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199264/
https://ncbi.nlm.nih.gov/pubmed/30352993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0284-6
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