Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development

Abnormalities of brain connectivity and signal transduction are consistently observed in individuals with schizophrenias (SZ). Underlying these anomalies, convergent in vivo, post mortem, and genomic evidence suggest abnormal oligodendrocyte (OL) development and function and lower myelination in SZ....

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Udgivet i:Transl Psychiatry
Main Authors: McPhie, Donna L., Nehme, Ralda, Ravichandran, Caitlin, Babb, Suzann M., Ghosh, Sulagna Dia, Staskus, Alexandra, Kalinowski, Amy, Kaur, Rupinderjit, Douvaras, Panagiotis, Du, Fei, Ongur, Dost, Fossati, Valentina, Eggan, Kevin, Cohen, Bruce M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6199264/
https://ncbi.nlm.nih.gov/pubmed/30352993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0284-6
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