Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis

Dysregulation of hepatic glucose production (HGP) serves as a major underlying mechanism for the pathogenesis of type 2 diabetes. The pancreatic hormone glucagon increases and insulin suppresses HGP, controlling blood glucose homeostasis. The forkhead transcription factor Foxo1 promotes HGP through...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Wu, Yuxin, Pan, Quan, Yan, Hui, Zhang, Kebin, Guo, Xiaoqin, Xu, Zihui, Yang, Wanbao, Qi, Yajuan, Guo, Cathy A., Hornsby, Caitlyn, Zhang, Lin, Zhou, Aimin, Li, Ling, Chen, Yunmei, Zhang, Weiping, Sun, Yuxiang, Zheng, Hongting, Wondisford, Fred, He, Ling, Guo, Shaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2018
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198346/
https://ncbi.nlm.nih.gov/pubmed/30201683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db18-0674
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