Structure of the human epithelial sodium channel by cryo-electron microscopy

The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na(+) and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel. Here, we present the structure of human ENaC in the uncleaved state det...

Full description

Saved in:
Bibliographic Details
Published in:eLife
Main Authors: Noreng, Sigrid, Bharadwaj, Arpita, Posert, Richard, Yoshioka, Craig, Baconguis, Isabelle
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2018
Subjects:
Structural Biology and Molecular Biophysics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197857/
https://ncbi.nlm.nih.gov/pubmed/30251954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39340
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items