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Structure of the human epithelial sodium channel by cryo-electron microscopy

The epithelial sodium channel (ENaC), a member of the ENaC/DEG superfamily, regulates Na(+) and water homeostasis. ENaCs assemble as heterotrimeric channels that harbor protease-sensitive domains critical for gating the channel. Here, we present the structure of human ENaC in the uncleaved state det...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Noreng, Sigrid, Bharadwaj, Arpita, Posert, Richard, Yoshioka, Craig, Baconguis, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197857/
https://ncbi.nlm.nih.gov/pubmed/30251954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39340
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