The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

The chemical diversity and known safety profiles of drugs previously tested in humans make them a valuable set of compounds to explore potential therapeutic utility in indications outside those originally targeted, especially neglected tropical diseases. This practice of “drug repurposing” has becom...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Janes, Jeff, Young, Megan E., Chen, Emily, Rogers, Nicole H., Burgstaller-Muehlbacher, Sebastian, Hughes, Laura D., Love, Melissa S., Hull, Mitchell V., Kuhen, Kelli L., Woods, Ashley K., Joseph, Sean B., Petrassi, H. Michael, McNamara, Case W., Tremblay, Matthew S., Su, Andrew I., Schultz, Peter G., Chatterjee, Arnab K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196526/
https://ncbi.nlm.nih.gov/pubmed/30282735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810137115
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