Pharmacological bypass of NAD(+) salvage pathway protects neurons from chemotherapy-induced degeneration

Axon degeneration, a hallmark of chemotherapy-induced peripheral neuropathy (CIPN), is thought to be caused by a loss of the essential metabolite nicotinamide adenine dinucleotide (NAD(+)) via the prodegenerative protein SARM1. Some studies challenge this notion, however, and suggest that an aberran...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Liu, Hui-wen, Smith, Chadwick B., Schmidt, Mark S., Cambronne, Xiaolu A., Cohen, Michael S., Migaud, Marie E., Brenner, Charles, Goodman, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196523/
https://ncbi.nlm.nih.gov/pubmed/30257945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1809392115
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